Raed Arafat: Explanations regarding the Vaccine against the Coronavirus

Raed Arafat explains the coronavirus

Raed Arafat is one of the supporters of the vaccination against the Coronavirus, as well as others from the Romanian Government who recommend people to take this step so that the Coronavirus pandemic can be overcome, and not only here, but also throughout the world.

Raed Arafat published below an explanation of what the composition of the vaccine should be, but also how it would work after administration, all with the idea of ​​convincing people that vaccination should be safe and effective.

"There are not many medicines/treatments that are more bio and organic than the vaccine against COVID-19. If we put the wheels in our heads in motion, it's not hard to see why.

The very short explanation -> "The theoretical and practical probability that the messenger RNA will enter the cell nucleus and be incorporated into the genome, i.e. modify the DNA of the vaccinated person, is zero. But let us still suppose that this could happen: then we would expect to see this phenomenon in retrovirally infected cells. However, such a phenomenon has never been observed". A detailed clarification here: the messenger RNA can never enter from the cytoplasm to the nucleus, not even in the case of retrovirally infected cells, because the enzyme necessary for such a thing is not present in our cytoplasm.

The excerpt above is the short answer given by Professor Katalin Kariko to the question of whether the anti-Covid-19 vaccine can change our DNA. Kariko is one of the two researchers who 15 years ago discovered the messenger RNA technology on which the current COVID-19 vaccine is based, and he agreed, with remarkable openness and simplicity, to help me clarify some of the the most frequently expressed concerns in Romania.

There is also a very simple version of the explanation, for those who did not get very good grades in biology in high school.
A student has a biology exam but doesn't feel like studying. Instead, he has an older and more demanding sister who, a year before, took the same exam. Sora duly went to the library (the nucleus of the cell where our DNA is found) and checked out the bio textbook there. The sister lends the transcripts (that is, the messenger RNA specific to the cell) to her brother, who cannot take them with him to the exam. They are too big for him to copy and he can catch him.

So he makes several small, fine copies (this is the messenger RNA made by the researchers and vaccine content) that he uses in the exam. With these little things, our student manages to get a 7 in the exam and pass the class honorably (that is, increase his immunity to the coronavirus to a satisfactory level). But that doesn't mean he actually went into the library and opened the original books (ie our DNA).

For those who got high marks in biology (without kids 🙂 ), some reminders and a slightly more detailed explanation.

Messenger RNA is a molecule used by cells to build their structures. It is not a protein, but it is essential in the process by which proteins (the building blocks of the human body) are made. Specifically, our cells use their own DNA as a template to synthesize messenger RNA in the nucleus. The messenger RNA is transported outside the nucleus, into the cytoplasm, where the information recorded on it is translated into proteins. The reverse process, where messenger RNA from the cytoplasm is transported back into the nucleus, is not possible, and as Kariko explains above, even if it were possible its effect has never been observed in nature.

What does the COVID-19 vaccine do? It contains a messenger RNA wrapped in a "little fat drop". The information that is translated into a protein specific to the coronavirus is recorded on this messenger RNA. But be careful, it is not the whole virus, not even its dead version that is introduced into our body. Only this messenger RNA is introduced into the body which will cause our cells to produce the respective antigen protein. This antigen is released on the surface of the cell where it is recognized by our immune system which, when it has the first contact with the real coronavirus, will already be prepared to root it out.

Why does the messenger RNA need to be wrapped in a "little fat drop"? Because RNA molecules are very easily degradable both in nature and in our body, thanks to the existence of specialized enzymes called RNases. The "tiny droplet" of fat protects the messenger RNA from these enzymes. There are thousands of scientific studies published over the last 30 years that prove beyond doubt that these "tiny fat droplets" (lipid nanoparticles) are biocompatible: they already exist naturally in our cell membranes.

The facts presented above also answer the question we received relatively often: why do we need to introduce foreign proteins into our body to fight the coronavirus?

First of all, it is not about proteins, but about much smaller molecules.

Second, these molecules are not foreign, they already exist in our body.

Third, they help our immune system effectively fight the real coronavirus when it infects us.

In other words, the vaccine against COVID-19 works even with the client's material. More organic and organic than that, practically impossible."